Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells

ABSTRACT: We identify miR-200c-3p as a microRNA to be enriched in cardiomyocyte (CM)-derived EVs under conditions of hypertrophic stress. This miRNA is transferred from CMs to cardiac endothelial cells (ECs) where it will impair endothelial cell function.RNA sequencing was performed to identify the mechanisms and genes that are under direct or indirect control of miR-200c and that could explain the phenotypes observed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE192586 | GEO | 2022/01/31

REPOSITORIES: GEO