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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [CUT&TAG]

ABSTRACT: Prdm1 encodes the transcriptional repressor PRDM1/BLIMP1 and Prdm1 mutant mice are one of the rare mutant strains that do not develop whisker hair follicles while still displaying a pelage. We demonstrate that Lef1, a key mediator of the Wnt/Beta Catenin pathway, acts upstream of Prdm1 and identify a primate specific deletion of a Lef1 enhancer, Leaf. This loss may have been significant in the evolutionary process, leading to the progressive defunctionalization and disappearance of vibrissae in primates.

ORGANISM(S): Mus musculus

PROVIDER: GSE192851 | GEO | 2022/10/19

REPOSITORIES: GEO

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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [4C-seq]

Project description:Prdm1 encodes the transcriptional repressor PRDM1/BLIMP1 and Prdm1 mutant mice are one of the rare mutant strains that do not develop whisker hair follicles while still displaying a pelage. We demonstrate that Lef1, a key mediator of the Wnt/Beta Catenin pathway, acts upstream of Prdm1 and identify a primate specific deletion of a Lef1 enhancer, Leaf. This loss may have been significant in the evolutionary process, leading to the progressive defunctionalization and disappearance of vibrissae in primates.

2022-10-19 | GSE193356 | GEO

The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry.

Project description:The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry.

| PRJNA795950 | ENA

The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [CUT&TAG]

Project description:The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [CUT&TAG]

| PRJNA793445 | ENA

The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [4C-seq]

Project description:The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [4C-seq]

| PRJNA795955 | ENA

Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta

Project description:Expression profiling of Prdm1 mutant E9.5 placenta was performed using Illumina whole genome V2 arrays. The hypothesis tested in the present study was that Blimp1 regulates the transcription of key genes involved in trophoblast differentiation. We demonstrate that the invading SpA-TGCs display robust Blimp1 expression and Blimp1 functional loss selectively disrupts specification of this discrete TGC sub-type. Transcriptional profiling experiments identified additional SpA-TGC lineage restricted marker genes that potentially regulate placental morphogenesis. Prdm1BEH/+ (Vincent et al., 2005) animals were intercrossed to generate null placental tissue. Total RNA obtained from 10 Prdm1+/+ and 11 Prdm1-/- E9.5 placenta samples was hybridized to Illumina WG6_V2 beadchips.

2012-07-23 | E-GEOD-39584 | biostudies-arrayexpress

Molecular function of Prdm1/Blimp1 in trophoblast giant cell differentiation.

Project description:Expression profiling of wild-type and Prdm1 null mouse trophoblast giant cell cultures using Illumina whole genome mouse V2 arrays. The hypothesis tested was that Prdm1/Blimp1 regulates expression of genes required for spiral artery trophoblast giant cell function. Prdm1 null and littermate control wild-type trophoblast stem cell clones were generated from blastocyst outgrowths. Total RNA was obtained from multiple replicates of four wild-type TS cell clones and four Prdm1 null TS cell clones differenitated for zero, two, four and six days by growth factor withdrawal and hybridized to Illumina WG6_V2 arrays

2016-03-14 | E-GEOD-74409 | biostudies-arrayexpress

The transcriptional repressor Blimp1/Prdm1 regulates post-natal reprogramming of intestinal enterocytes

Project description:Expression profiling of Prdm1 mutant E18.5 small intestine was performed using Illumina whole genome V2 arrays. The hypothesis tested in the present study was that Blimp1 regulates the transcription of key genes involved in enterocyte differentiation and survival. Results identify substantial and premature activation of key components of the adult enterocyte biochemical signature. Villin-Cre and Prdm1BEH/+ animals were intercrossed to generate heterozygous Villin-Cre, Prdm1BEH males that were then mated with homozygous Prdm1 CA/CA females carrying the R26R allele to generate Prdm1+/+ (Prdm1CA/+) or Prdm1-/- (Villin-Cre, Prdm1CA/BEH) offspring. Total RNA obtained from 11 Prdm1+/+ and 10 Prdm1-/- E18.5 small intestine samples was hybridized to Illumina WG6_V2 beadchips.

2011-06-02 | E-GEOD-29658 | biostudies-arrayexpress

Molecular function of Prdm1/Blimp1 in trophoblast giant cell differentiation.

2016-03-14 | GSE74409 | GEO

Prdm1

Project description:Prdm1

| PRJNA300302 | ENA

Expression data from GFP control and GFP-PRDM1 transduced H9 hESCS

Project description:The mechanisms of transcriptional regulation underlying human primordial germ cell differentiation are largely unknown. Transcriptional repressor Prdm1/Blimp1 is known to play a critical role in controlling germ cell specification in mice. We show that ectopic expression of PRDM1 in hESCs promotes the generation of cells exhibiting transcriptomic features of early primordial germ cells.

2016-12-11 | GSE53283 | GEO

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