Transcriptomics

Dataset Information

0

Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients


ABSTRACT: Macrophage infiltration is a hallmark of solid cancers and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor- associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with antagonistic roles on cancer progression and on the development of anti-tumor immunity. Here, we identify a discrete population of FOLR2 + tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2 + macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8 + T cells. Moreover, FOLR2 + macrophages efficiently prime effector CD8 + T cells ex vivo . The density of FOLR2 + macrophages in tumors positively correlates with better patient survival. This study highlights antagonistic roles for tumor-associated macrophage subsets and paves the way for subset-specific therapeutic interventions in macrophages-based cancer therapies.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE192935 | GEO | 2022/01/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2017-05-04 | E-MTAB-5640 | biostudies-arrayexpress
2023-05-16 | GSE227560 | GEO
2022-01-07 | GSE188647 | GEO
2023-04-11 | PXD036940 | Pride
2017-03-31 | PXD005080 | Pride
2020-11-01 | GSE155841 | GEO
2022-03-08 | GSE161769 | GEO
2022-03-08 | GSE161768 | GEO
| PRJNA655737 | ENA
2022-02-09 | GSE193168 | GEO