Cell type influences metastasis tropism
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ABSTRACT: We report that the cell of origin plays an important role in this metastatic tropism. Following injection into the arterial circulation of mice, each of the identically transformed cell types gave rise to different metastatic patterns. Using gene expression analysis, we identified the chemokine receptor CXCR4 as being instrumental in determining the distinct metastatic patterns between skeletal muscle precursor cells and skeletal myoblasts.
ORGANISM(S): Homo sapiens
PROVIDER: GSE19294 | GEO | 2016/02/13
SECONDARY ACCESSION(S): PRJNA120875
REPOSITORIES: GEO
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