Differential expression and pathway enrichment in neutrophils treated with Ruxolitinib and vehicle

ABSTRACT: We report the effect of rexolitinib on neutrophil function, by extracting mouse bone marrow neutrophils, and after treatment with Ruxolitinib and vehicle, extracting neutrophil RNA from each group for RNA-seq. Finally, we show that Ruxolitinib produces functional effects on neutrophils mainly through inflammatory signaling pathways, amplifying the immune effects of neutrophils in an inflammatory environment and accelerating neutrophil death.

ORGANISM(S): Mus musculus

PROVIDER: GSE193055 | GEO | 2022/01/04

REPOSITORIES: GEO