Differential expression and pathway enrichment in neutrophils treated with Ruxolitinib and vehicle
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ABSTRACT: We report the effect of rexolitinib on neutrophil function, by extracting mouse bone marrow neutrophils, and after treatment with Ruxolitinib and vehicle, extracting neutrophil RNA from each group for RNA-seq. Finally, we show that Ruxolitinib produces functional effects on neutrophils mainly through inflammatory signaling pathways, amplifying the immune effects of neutrophils in an inflammatory environment and accelerating neutrophil death.
ORGANISM(S): Mus musculus
PROVIDER: GSE193055 | GEO | 2022/01/04
REPOSITORIES: GEO
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