Transcriptomics

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Longitudinal Immune Profiling Highlights CD4+ T cell Exhaustion Correlated with Liver Fibrosis in Schistosoma japonicum Infection


ABSTRACT: Schistosoma japonicum causes severe disease or even death and liver fibrosis is the major damage, which is caused by immunopathological injury. However, a comprehensive understanding of the immune cell changes during S. japonicum infection is lacking. Here, we performed single-cell RNA-sequencing and T/B cell receptor sequencing (scRNA-seq/scTCR-seq/scBCR-seq) of the total mouse splenocytes after cercaria infection.The changes of immune cells with advancing disease stages were analyzed and the relationship with liver fibrosis was investigated.

ORGANISM(S): Mus musculus

PROVIDER: GSE193216 | GEO | 2022/11/01

REPOSITORIES: GEO

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