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An intersegmental single-cell profile reveals aortic heterogeneity [aorta]

ABSTRACT: The continuous inter-segmental aortic profile has been rarely reported at the single-cell level. To reveal aortic heterogeneity, we identified 15 cell subtypes from five continuous aortic segments by marker genes and functional definitions. In conclusion, our study provides a more comprehensive segmental single-cell transcriptome of the aorta at the physiological level, inspiring new ideas for diagnosis and intervention targets in the pathogenesis of aortic diseases. Furthermore, a novel construction system of VSMCs was proposed to replace the traditional classification.

ORGANISM(S): Mus musculus

PROVIDER: GSE193265 | GEO | 2022/05/02

REPOSITORIES: GEO

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