Transcriptomics

Dataset Information

0

Listeria monocytogenes induces T cell receptor unresponsiveness via its pore-forming toxin listeriolysin O


ABSTRACT: The success of many pathogens relies on their ability to circumvent the innate and adaptive immune defenses. How bacterial pathogens subvert host responses is not clear. Cholesterol-dependent cytolysins (CDCs) represent an expansive family of homologous pore-forming toxins produced by more than 20 Gram-positive bacterial species. Here we show that listeriolysin O (LLO), a prototype CDC produced by Listeria monocytogenes, inhibits antigen receptor-induced T cell proliferation. In vivo proliferation of OT II T cells was highly diminished in the presence of wild type but not the LLO-deficient bacteria. T cells pre-exposed to LLO ex vivo were also impaired in proliferation upon TCR activation in vivo and in vitro. Our results suggest that LLO-induced T cell unresponsiveness is due to the sub-threshold activation of T cells via the induction of a calcium-NFAT dependent transcriptional program that drives the expression of negative regulators of TCR signaling. Keywords: Listerilysin O, Ionomycin, 3 hours stimulation

ORGANISM(S): Mus musculus

PROVIDER: GSE19337 | GEO | 2010/06/29

SECONDARY ACCESSION(S): PRJNA121707

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-07-29 | E-GEOD-19337 | biostudies-arrayexpress
2018-11-07 | PXD006996 | Pride
2018-11-07 | PXD006900 | Pride
2018-05-17 | PXD009339 | Pride
2020-02-28 | GSE146069 | GEO
2008-04-01 | E-MEXP-1078 | biostudies-arrayexpress
2011-10-02 | E-GEOD-32505 | biostudies-arrayexpress
2023-05-23 | PXD042419 | JPOST Repository
2022-12-21 | PXD038868 | JPOST Repository
2011-10-03 | GSE32505 | GEO