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Regulation of Liver metabolism by ALKBH1

ABSTRACT: AlkB homolog 1 (ALKBH1) has been reported to act as a DNA 6mA demethylase to remove 6mA modificatione in ukaryotic genomes. Our previous data showed downregalted ALKBH1 in mouse and human fatty liver and increased DNA 6mA levels in mouse fatty liver. We hypothesize that ALKBH1 may be involved in hepatic lipid metabolism. To test this hypothesis, we generated liver-specific ALKBH1 knockout (Alkbh1 f/f, Albumine-cre; AKO) mice and used high-throughput RNA sequence and other assays to directly study the role of ALKBH1 during the development of hepatic steatosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE193497 | GEO | 2022/10/26

REPOSITORIES: GEO

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Regulation of Liver metabolism by ALKBH1

Project description:Regulation of Liver metabolism by ALKBH1

| PRJNA796362 | ENA