Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation
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ABSTRACT: Alzheimer’s disease (AD) is characterized by neuroinflammation, accumulation of amyloid-β (Aβ) plaques and neuronal degeneration in the brain. The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset AD. ApoE interacts with complement regulator factor H (FH) but the role of this interaction in AD pathogenesis is unknown.
ORGANISM(S): Homo sapiens
PROVIDER: GSE193513 | GEO | 2023/05/03
REPOSITORIES: GEO
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