Transcriptomics

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Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation


ABSTRACT: Alzheimer’s disease (AD) is characterized by neuroinflammation, accumulation of amyloid-β (Aβ) plaques and neuronal degeneration in the brain. The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset AD. ApoE interacts with complement regulator factor H (FH) but the role of this interaction in AD pathogenesis is unknown.

ORGANISM(S): Homo sapiens

PROVIDER: GSE193513 | GEO | 2023/05/03

REPOSITORIES: GEO

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