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Transcriptional profiling of conditional knockout mice lacking Izumo1r in FoxP3+ Tregulatory cells

ABSTRACT: We reported transcriptional characterization of splenic, ear skin and back skin of Izumo1R flox X Foxp3Cre mice and littermate controls. We report few changes observed in splenic Tregs but changes seen in the whole skin transcriptome and gamma delta compartment starting at approximately 8 weeks of age. We report upregulation of inflammatory genes overlapping with genes upregulated in the skin following topical administration of Imiquimod.

ORGANISM(S): Mus musculus

PROVIDER: GSE193572 | GEO | 2022/01/19

REPOSITORIES: GEO

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