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RDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - ATACseq

ABSTRACT: In this study we perform ATAC-seq of budding yeast strains with variable copy number of the rRNA genes (rDNA CN). We aim to better understand the relationship between DNA accessibility and replicative lifespan in strains with variable rDNA CN.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE193598 | GEO | 2022/04/05

REPOSITORIES: GEO

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rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - RNAseq

Project description:In this study we perform RNA-seq of budding yeast strains with variable copy number of the rRNA genes (rDNA CN) to assess the relationship between rDNA CN and gene expression. RNA-seq was performed on samples both with and without polyA selection (for all transcripts and for rRNA transcripts, respectively).

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rDNA array length is a major determinant of replicative lifespan in budding yeast.

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rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - ATACseq

Project description:rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - ATACseq

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Project description:This SuperSeries is composed of the SubSeries listed below.

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rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast.

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Depletion of limiting rDNA structural complexes triggers chromosomal instability and replicative aging of Saccharomyces cerevisiae

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