Gene expression changes in mouse forebrain deficient in Dnmt1 and Dnmt3a
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ABSTRACT: Two major DNA methylation-catalyzing enzymes, Dnmt1 and Dnmt3a, are expressed in postmitotic neurons, but their function in the adult central nervous system is unclear. We generated conditional mutant mice (CamKIIa Cre; Dnmt loxP) that lack either Dnmt1 or Dnmt3a, or both, exclusively in forebrain excitatory neurons and found only double-knockout (DKO) mice exhibited abnormal hippocampal CA1 long-term plasticity and deficits of learning and memory. DKO neurons also exhibit a significant up-regulation of immune genes, such as class I MHC and Stat1, which are implicated in synaptic plasticity.
ORGANISM(S): Mus musculus
PROVIDER: GSE19367 | GEO | 2010/12/03
SECONDARY ACCESSION(S): PRJNA120407
REPOSITORIES: GEO
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