Regulation of alternative splicing by histone modifications
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ABSTRACT: Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. Here, we demonstrate a direct role for histone modifications in alternative splicing. We find distinctive histone modification signatures which correlate with splicing outcome in a set of human genes. Modulation of histone modifications causes splice site switching. The mechanism for histone-mediated splice site selection involves a histone mark which is read by a chromatin protein, which in turn recruits a splicing regulator. These results outline an adaptor system for reading of histone marks by the pre-mRNA splicing machinery.
ORGANISM(S): Homo sapiens
PROVIDER: GSE19373 | GEO | 2010/02/10
SECONDARY ACCESSION(S): PRJNA120419
REPOSITORIES: GEO
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