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Estrogen Modulation of the Pronociceptive Effects of Serotonin on Female Rat Trigeminal Sensory Neurons is Timing- and Dosage-Dependent and Requires Estrogen Receptor Alpha

ABSTRACT: Since estrogen is a major hormone involved in multiple gene expression pathways in the cell, we wanted to determine the corresponding changes in trigeminal ganglia transcriptome of the E2-treated rats. Adult ovariectomized female rats were subcutaneneously implanted with either 5% (physiological level comparable to diestrus; 15-20 pg/ml; one capsule), 20% (physiological level comparable to proestrus; 40-60 pg/ml; 2 capsules of 10%), 40% (supraphysiological level; 2 capsules of 20%) E2, or control (2 capsules of 100% cholesterol) capsules. One week after implantation, nocifensive behaviors were recorded and trigeminal ganglia tissue was extracted.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE193773 | GEO | 2022/03/31

REPOSITORIES: GEO

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