Gene expression profiles in the cultured dorsal root ganglia (DRG) neurons treated with PBS or oncomodulin (ONCM)

ABSTRACT: Preconditioning nerve injury drives pro-regenerative perineuronal macrophage activation in dorsal root ganglia (DRG). The present study reports that oncomodulin (ONCM) is produced from the regeneration-associated macrophages (RAMs) and strongly influences regeneration of DRG sensory axons. ONCM in macrophages was necessary to produce RAMs in the in vitro model of neuron-macrophage interaction and played an essential role in for preconditioning-induced neurite outgrowth. In order to gain insight on potential mechanisms downstream of ONCM for potent neurite outgrowth activity, we performed RNA-seq using cultured DRG neurons treated with ONCM.

ORGANISM(S): Mus musculus

PROVIDER: GSE193893 | GEO | 2022/01/21

REPOSITORIES: GEO