Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Taurocholate acid signals a specific gene expression reprogramming affecting amino-acids and nucleotides metabolisms

ABSTRACT: Enterococcus faecalis is a natural inhabitant of the human gastrointestinal tract. In a healthy physiological state of the gut (eubiosis), E. faecalis is a subdominant species in the intestinal microbiota. When the intestinal homeostasis is disrupted (dysbiosis), it becomes dominant species and can cause infections. The taurocholate bile acid (TCA) becomes prominent during dysbiosis. This experiment aimed to better understand how E. faecalis adapts to TCA. We showed that TCA reprograms genes involved in the pool management of amino acids and nucleotides.

ORGANISM(S): Enterococcus faecalis

PROVIDER: GSE194009 | GEO | 2022/05/20

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression in response to deoxycholate acid constraints growth of Enterococcus faecalis

Project description:Enterococcus faecalis is a natural inhabitant of the human gastrointestinal tract. In a healthy physiological state of the gut (eubiosis), E. faecalis is a subdominant species in the intestinal microbiota. When the intestinal homeostasis is disrupted (dysbiosis), it becomes dominant species and can cause infections. The prominence of bile acids deoxycholate (DCA) hallmarks eubiosis. This experiment aimed to better understand how E. faecalis adapts to DCA. We showed that DCA impairs E. faecalis growth and imposes permanent adjustments to the expression of many crucial genes, including a majority of factors enabling translation. Thus, the drastic decrease of DCA amounts during dysbiosis may account for the rise of E. faecalis population.

2022-05-20 | GSE192438 | GEO

Taurocholate acid signals a specific gene expression reprogramming affecting amino-acids and nucleotides metabolisms

Project description:Taurocholate acid signals a specific gene expression reprogramming affecting amino-acids and nucleotides metabolisms

| PRJNA798735 | ENA

Guzior et al - C. perfringens BSH/T

Project description:E. coli DH5a expressing bile salt hydrolase variants in the presence of 1 mM glycocholate (GCA), taurocholate (TCA), or cholate (CA).

2023-06-09 | MSV000092138 | MassIVE

Transcription profiling of brain tissue from trout with different dominace status

Project description:Dominance hierarchies of rainbow trout Trout form linear dominance hierarchies where there is a dominant, subdominant and subordinate. The dominant is the most aggressive, followed by the subdominant and the subordinate is the least dominant. Fish were scored on their aggressive performance to calculate position within the hierarchy, and once formed the hierarchies are very stable. Hypothesis: Gene expression is different in the brains of individuals with different dominance status. Six hierarchies containing a dominant, subdominant and subordinate were assessed behaviourally then killed and the brain removed. These were run in a reference based design. Hypothesis: On removal of the dominant the subdominant fish will become dominant and its transcript profile will become similar to the established dominant. The second experiment involved removing the dominant from an established hierarchy and then examining gene expression at 2hr, 48hr and 1 week in the new dominant.

2011-04-05 | E-MAXD-33 | biostudies-arrayexpress

Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use [RNA-seq]

Project description:To uncover the role of opioid induced dysbiosis in disrupting intestinal homeostasis, we conducted a multi-omics analysis with gut microbial, metabolite and intestinal transcriptomics data

2023-08-30 | GSE230095 | GEO

Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use [ABX-RNA seq]

2023-08-30 | GSE230093 | GEO

Nucleotides affect zebrafish microbiota

Project description:The effect of nucleotides on the intestinal microbiota of zebrafish

| PRJEB19156 | ENA

Higher colonic proliferation and tumor prevalence amongst azoxymethane treated A/J mice receiving fecal microbiota transplants from old mice compared to recipients of young mice [16S rRNA-Seq]

Project description:Gut microbial dysbiosis can play a causal role of in colorectal cancer. Gut microbiota chnages with age and becomes moer pro-inflammatory. We sought to determine whether microbiota from Old donors promotes more tumor formation in recipients than meterial from young donors.

2023-11-30 | GSE237336 | GEO

Higher colonic proliferation and tumor prevalence amongst azoxymethane treated A/J mice receiving fecal microbiota transplants from old mice compared to recipients of young mice [RNA-Seq]

2023-11-30 | GSE237335 | GEO

NOD2-dependent licensing of the microbiota predispose to transmissible inflammation and tumorigenesis in the colon.

Project description:Instability in the composition of gut bacterial communities, referred as dysbiosis, has been associated with important human intestinal disorders such as Crohn’s disease and colorectal cancer. Here, we show that dysbiosis coupled to Nod2 or Rip2 deficiency suffices to cause an increased risk for intestinal inflammation and colitis-associated carcinogenesis in mice. Aggravated epithelial lesions and dysplasia upon chemical-induced injury associated with loss of Nod2 or Rip2 can be prevented by antibiotics or anti-IL6R treatment. Nod2-mediated risk for intestinal inflammation and colitis-associated tumorigenesis is communicable through maternally-transmitted microbiota even to wild-type hosts. Disease progression was identified to drive complex NOD2-dependent changes of the colonic-associated microbiota. Reciprocal microbiota transplantation rescues the vulnerability of Nod2-deficient mice to colonic injury. Altogether, our results unveil an unexpected function for NOD2 in shaping a protective assembly of gut microbial communities, providing a rationale for intentional manipulation of genotype-dependent dysbiosis as a causative therapeutic principle in chronic intestinal inflammation.

2013-01-02 | GSE32421 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data