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Transcriptomic analysis of the spiral ganglion from hearing and aminoglycoside deafened rats

ABSTRACT: We used RNAseq to assess transcriptomic changes in the spiral ganglion of rats deafened with kanamycin compared to hearing control rats to gain a better understanding of the deafening-induced changes that occur in the spiral ganglion. Transcriptomic profiles were obtained from whole spiral ganglion from hearing and deafened rats at P32 and P60. We observed significant changes in gene expression in not only deafened compared to hearing ganglia, but also from P32 to P60 in normal hearing animals. The most prominent change after deafening was an increase in immune response-related gene expression, indicating that immune response activation occurs in the deafened spiral ganglion.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE194063 | GEO | 2024/06/01

REPOSITORIES: GEO

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Microarray expression profiling of the spiral ganglion of hearing and deafened rats

Project description:Gene expression profiling of apical and basal halves of the spiral ganglion of hearing and kanamycin-deafened rats at P32 and P60 was performed using microarray analysis. The data are further described in Rahman MT, Bailey EM, Gansemer BM, Pieper AA, Manak JR, and Green SH. Anti-inflammatory compounds improve spiral ganglion neuron survival after aminoglycoside-induced hair cell loss in rats.

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The upregulation of K+ and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells

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