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Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension [pul31]

ABSTRACT: Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that culminates in right heart failure. Vascular pathology in PH is characterized by pulmonary vasoconstriction and progressive vascular remodeling processes that affects all layers of the vascular wall (intima, media and adventitia). Our objective was to profile and analyze the differential gene expression signatures between the cells isolated from normal and idiopathic PAH patients. We generated vascular cell-specific transcriptome profiles from the adventitial fibroblasts (PAAF) isolated ex vivo from the dissected human pulmonary arteries of normal donor and PAH lungs using paired-end RNA-sequencing.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE194067 | GEO | 2022/06/09

REPOSITORIES: GEO

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Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension [pul35]

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