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Legumain dependent gene signatures in stromal progenitors

ABSTRACT: LGMN has been shown to regulate cell fate decission of stromal progenitors of the bone. To understabnd the underlying mechanisms and gene signatures that are responsive to elevated or diminished levels of LGMN we performed RNA-seq analysis on stable cell lines with diminished (LGMN knockdown) or elevated (LGMN overexpression) levels of LGMN at the progenitor level. Genes responsive to LGMN levels show invers dynamics during osteoblast and adipocyte differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE194287 | GEO | 2024/01/01

REPOSITORIES: GEO

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