3D chromatin architecture of drug-tolerant cancer cells at single-cell resolution [scHi-C]

ABSTRACT: Anticancer drug therapy generally elicits the drug tolerance after long-term treatment. Recent studies suggested that 3D chromatin structures of cancer cells were intimately linked to drug resistance. However, 3D chromatin structures in drug-tolerant cancer cells at single-cell resolution haven’t been elucidated. Here we performed single-cell Hi-C (scHi-C) analysis to examine the 3D chromatin structures in three stages of breast cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE194308 | GEO | 2024/08/14

REPOSITORIES: GEO