Esophageal keratinocyte invasion after loss of E-cadherin and TGF receptor type II
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ABSTRACT: Esophageal cancer is one of the deadliest cancers as patients present at late stages of disease. Frequent gene alterations include the loss of E-cadherin and TGFb receptor type II. The goal of this study was to establish a model of esophageal cancer by introducing dominant-negative mutants of E-cadherin and TGFb receptor II. To analyze the functional consequences and gene expression chages induced by E-cadherin and TGFb receptor type II loss in esophageal cancer.
ORGANISM(S): Homo sapiens
PROVIDER: GSE19472 | GEO | 2013/11/12
SECONDARY ACCESSION(S): PRJNA120349
REPOSITORIES: GEO
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