RNA-sequencing of iPSC-derived blood-brain barrier cell types across microenvironments
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ABSTRACT: The blood-brain barrier (BBB) is lined by brain microvascular endothelial cells (BMECs) which regulate transport into and out of the brain. We used human induced pluripotent stem cell (iPSC)-derived cell types to model BBB function within 2D and 3D in vitro models. We compare gene expression between different iPSC-derived cell types, and specifically profile the response of iPSC-derived BMEC-like cells (iBMECs) to differentiation media volume, microenvironmental cues, and cytokines.
ORGANISM(S): Homo sapiens
PROVIDER: GSE195519 | GEO | 2022/01/30
REPOSITORIES: GEO
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