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Quantitative analysis of tet inducible SOX18 during hematopoietic differentiation and Natural killer cell differentiation

ABSTRACT: Using inducible SOX18 human PSCs, we found overexpression of SOX18 showed change of transcriptional program at D8 especially T cell receptor and Toll like receptor signaling pathways. So this suggests SOX18 has an effect on lymphoid differentiation program. Specifically overexpressed SOX18 enhance NK cell production, and related to metabolism pathway. This finding that SOX18 promotes development of progenitors with superior NK cell potenital will advance our understanding of molecualr network regulating specification on lymphoid cells and can help to improve the scalability of NK CELL production form hPSCs form immunotherapies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE195670 | GEO | 2023/03/20

REPOSITORIES: GEO

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