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Single Nuclei Transcriptomics Delineates Complex Interactions Between Immune and Renal Cells Contributing to Kidney Graft Fibrosis

ABSTRACT: Purpose: Chronic allograft dysfunction (CAD) remains a major obstacle in kidney transplantation. However, the molecular pathogenesis of human CAD is unknown. Herein, we tested the hypothesis that single nuclei transcriptomics of human kidney allograft fibrosis will reveal diverse cell types, deconvolve complex fibrosis-driving pathways, and provide deeper insights into the progression of kidney allograft dysfunction.

ORGANISM(S): Homo sapiens

PROVIDER: GSE195718 | GEO | 2023/03/06

REPOSITORIES: GEO

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Molecular Profiles Associated with Calcineurin Inhibitor Toxicity Post-Kidney Transplant: Input to Chronic Allograft Dysfunction

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Homo sapiens

Project description:Renal allograft dysfunction (kidney tissue data set)

| PRJNA136219 | ENA

Expression data from kidney transplantations in a Fisher-Lewis rat model: placebo and 13cisRA treatment

2012-01-07 | GSE17045 | GEO

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