Establish the mechanism of the effect of panobinostat on murine Pax2+ renal progenitors.
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ABSTRACT: We generated single-cell RNA sequencing (scRNAseq) datasets of primary cultures of mouse Pax2+ renal progenitors isolated from healthy mice and treated in vitro with vehicle or the HDAC inhibitor panobinostat. Pax2+ cells expressed progenitor cells markers in absence of tubular and endothelial cell markers and following treatment with panobinostat, upregulated the expression of podocyte-specific markers.
ORGANISM(S): Mus musculus
PROVIDER: GSE195785 | GEO | 2022/09/23
REPOSITORIES: GEO
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