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Blood transcriptomes of SARS-CoV-2 infected kidney transplant recipients demonstrate immune insufficiency

ABSTRACT: Kidney transplant recipients (KTRs) are reported to have worse outcomes with COVID-19, and empiric reduction of T-cell directed immunosuppression has been pursued. Here we evaluated the peripheral blood transcriptome of 64 KTRs either during and after acute COVID-19. We identified transcriptomic signatures of suppression of adaptive T-cell responses which significantly associated with disease severity and showed evidence of recovery after acute disease. These findings were consistent with public data from non-KTR cohorts.

ORGANISM(S): Homo sapiens

PROVIDER: GSE195796 | GEO | 2022/07/15

REPOSITORIES: GEO

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