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Mouse embryonic kidneys (E13.5): HDAC inhibitor (HDACi) treated vs. Control

ABSTRACT: Transcriptional profiling of cultured CD1 mouse embryonic kidneys (E13.5) comparing HDACi-treated kidneys with control drug-treated kidneys. Studies in our lab showed that pharmacological inhibition of HDAC activity in ex-vivo cultured metanephroi results in extensive defects in kidney development, including impaired UB branching, tubulogenesis, and glomerulogenesis, accompanied by cell cycle arrest and apoptosis.The goal of the microarray analysis was to elucidate the morphogenetic pathways affected by HDACi.

ORGANISM(S): Mus musculus

PROVIDER: GSE19581 | GEO | 2010/08/01

SECONDARY ACCESSION(S): PRJNA122353

REPOSITORIES: GEO

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Mouse embryonic kidneys (E13.5): HDAC inhibitor (HDACi) treated vs. Control

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