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The multifaceted role of GCM1 during trophoblast differentiation in the human placenta

ABSTRACT: Human trophoblast stem cells were infected with lentivirus to knockdown the transcription factor GCM1. RNA-seq was then utilized to determine global transcriptomic changes between control and GCM1-deficient human trophoblasts either cultured as cytotrophoblasts or induced to form extravillous trophoblasts. This study provides insight into the molecular mechanisms regulating extavillous trophoblast development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE196259 | GEO | 2022/10/22

REPOSITORIES: GEO

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