Transcriptomics

Dataset Information

0

Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis


ABSTRACT: Brain metastasis is a significant cause of morbidity and mortality in multiple cancer types and represents an unmet clinical need. The mechanisms that mediate metastatic cancer growth in the brain parenchyma are largely unknown. Melanoma, which has the highest rate of brain metastasis among common cancer types, is an ideal model to study how cancer cells adapt to the brain parenchyma. Our unbiased proteomics analysis of melanoma short-term cultures revealed that proteins implicated in neurodegenerative pathologies are differentially expressed in melanoma cells explanted from brain metastases compared to those derived from extracranial metastases. We showed that melanoma cells require amyloid beta (Ab) for growth and survival in the brain parenchyma. Melanoma-secreted Ab activates surrounding astrocytes to a prometastatic, anti-inflammatory phenotype and prevents phagocytosis of melanoma by microglia. Finally, we demonstrate that pharmacological inhibition of Ab decreases brain metastatic burden.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE196332 | GEO | 2022/02/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-02-10 | MSV000088814 | MassIVE
2014-05-08 | E-GEOD-50493 | biostudies-arrayexpress
2014-05-08 | E-GEOD-50495 | biostudies-arrayexpress
2013-09-19 | E-GEOD-44019 | biostudies-arrayexpress
| PRJNA217773 | ENA
2020-09-17 | GSE137687 | GEO
2013-09-19 | E-GEOD-44660 | biostudies-arrayexpress
2023-01-18 | GSE203152 | GEO
2022-07-06 | GSE200217 | GEO
2022-07-06 | GSE205033 | GEO