Genome-wide maps of H3K27ac and H3K4me1 in primary normal fibroblasts and matched cancer-associated fibroblasts
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ABSTRACT: To understand the driving mechanisms for CAF activation, we performed H3K27ac and H3K4me1 Cleavage Under Targets and Tagmentation (CUT&Tag) analysis in six pairs of NFs and CAFs. At H3K4me1+ sites, we identified 3,333 regions with H3K27ac levels in CAFs ≥ 2-fold than matched NFs in more than 3 pairs, and defined them as CAF-activated enhancers.
ORGANISM(S): Homo sapiens
PROVIDER: GSE196348 | GEO | 2022/12/09
REPOSITORIES: GEO
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