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Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumor

ABSTRACT: We proved that histone H3K27me3 and H3K27ac were elevated in AT/RT cells and distributed in distinct chromatin regions to regulate specific gene expression and to promote AT/RT growth. Targeting EZH2 and BRD4 activity is therefore a potential combination therapy for AT/RT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE196440 | GEO | 2022/02/10

REPOSITORIES: GEO

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Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumor [RNA-Seq]

Project description:We proved that histone H3K27me3 and H3K27ac were elevated in AT/RT cells and distributed in distinct chromatin regions to regulate specific gene expression and to promote AT/RT growth. Targeting EZH2 and BRD4 activity is therefore a potential combination therapy for AT/RT.

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Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumor

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