Transcriptomics

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Bach2 negatively regulates natural killer cell maturation and effector program


ABSTRACT: Bach2 has been reported to regulate multiple immune cell development and function. Here we report that Bach2 is constitutively expressed in relatively immature NK subsets. Bach2 negatively regulates NK cell development and Bach2 deficiency results in NK cell with mature effector phenotype. Thus, Bach2 functions as a negative regulator of NK cell maturation and function.

ORGANISM(S): Mus musculus

PROVIDER: GSE196530 | GEO | 2022/02/10

REPOSITORIES: GEO

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