Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE196613 | GEO | 2022/10/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [RNA-seq]

Project description:A new sorting protocol was used to identify and isolate different senescent cell types from damaged muscles of young and geriatric mice. Analysis revealed conservation of two universal senescence hallmarks (inflammation and fibrosis) across cell type, regeneration time, and aging, while cell identity traits were preserved. Senescent cells create an “aged-like” inflamed niche, mirroring inflammation-associated with aging (inflammaging), that arrests stem cell proliferation and regeneration.

2022-10-25 | GSE196611 | GEO

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [scRNA-seq]

2022-10-25 | GSE197017 | GEO

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [ATAC-seq]

2022-10-25 | GSE196612 | GEO

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime

Project description:A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime

| PRJNA806157 | ENA

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [RNA-seq]

Project description:A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [RNA-seq]

| PRJNA806162 | ENA

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [scRNA-seq]

Project description:A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [scRNA-seq]

| PRJNA808400 | ENA

A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [ATAC-seq]

Project description:A skeletal-muscle senescence blueprint defines an aged-like inflamed niche that inhibits regeneration over lifetime [ATAC-seq]

| PRJNA806161 | ENA

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration.

Project description:Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration at all stages of life. The technical limitation of senescent-cell scarcity3 was overcome by combining single-cell transcriptomics and a senescent-cell enrichment sorting protocol. We identified and isolated different senescent cell types from damaged muscles of young and old mice. Deeper transcriptome, chromatin and pathway analyses revealed conservation of cell identity traits as well as two universal senescence hallmarks (inflammation and fibrosis) across cell type, regeneration time and ageing. Senescent cells create an aged-like inflamed niche that mirrors inflammation associated with ageing (inflammageing4) and arrests stem cell proliferation and regeneration. Reducing the burden of senescent cells, or reducing their inflammatory secretome through CD36 neutralization, accelerates regeneration in young and old mice. By contrast, transplantation of senescent cells delays regeneration. Our results provide a technique for isolating in vivo senescent cells, define a senescence blueprint for muscle, and uncover unproductive functional interactions between senescent cells and stem cells in regenerative niches that can be overcome. As senescent cells also accumulate in human muscles, our findings open potential paths for improving muscle repair throughout life.

| S-EPMC9812788 | biostudies-literature

A Blueprint for Characterizing Senescence.

Project description:Given the heterogeneity of senescent cells, our knowledge of both the drivers and consequences of cellular senescence in tissues and organs remains limited, as is our understanding of how this process could be harnessed for human health. Here we identified five broad areas that would help propel the field forward.

| S-EPMC8364378 | biostudies-literature

Neural crest lineage segregation: a blueprint for periodontal regeneration.

Project description:During the recent decade, the periodontal attachment apparatus has become one of the premier areas of the body for the development of novel tissue-engineering strategies. In the present review, we describe a developmental biology approach to characterize current concepts in periodontal regeneration and to discuss strategies for future applications in periodontal therapies. To decipher the developmental make-up of the periodontal region, we have followed the path of the migratory neural crest, since it gives rise to periodontal progenitor tissues, which in turn are subjected to the influence of diverse craniofacial extracellular matrices and peptide growth factors. Based on this developmental perspective, we have conducted a systematic analysis of the factors, progenitor cells, and matrices used in current periodontal tissue-engineering approaches. We propose that the developmental history of a tissue is a highly instructive design template for the discovery of novel bioengineering tools and approaches.

| S-EPMC2749262 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data