Transcriptomics

Dataset Information

0

A bleomycin induced murine model of scleroderma in GSDMD-/- versus wild type


ABSTRACT: The NLRP3 inflammasome and IL-1β are essential for scleroderma pathogenesis. Nevertheless, the role of pyroptosis executor gasdermin D(GSDMD), which is a downstream molecule of NLRP3 and is required for IL-1β release in some situations, has not yet been well elucidated in scleroderma. The purpose of this study was to explore the differences in the degree of skin fibrosis between GSDMD-/- and wild type mice in a bleomycin-induced scleroderma model, and the molecular pathways that may be involved.Total RNA from skin biopsies from GSDMD-/- and wild type mice after subcutaneous injection of BLM to induce skin fibrosis was examined by nextGen RNA sequencing

ORGANISM(S): Mus musculus

PROVIDER: GSE196637 | GEO | 2022/02/16

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-02-17 | PXD029017 | Pride
2023-09-18 | GSE217363 | GEO
2024-02-25 | GSE252911 | GEO
2024-02-25 | GSE252893 | GEO
2024-07-29 | GSE250049 | GEO
2024-04-19 | GSE264184 | GEO
2022-01-05 | GSE181872 | GEO
2023-09-20 | GSE240009 | GEO
2022-04-13 | GSE200560 | GEO
2020-07-06 | GSE137827 | GEO