Transcriptomics

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Expression data of penile carcinomas and normal penis


ABSTRACT: Penile carcinoma (PeCa) is a rare cancer with orphan disease designation and a prevalence of 0.1-1 per 100,000 men in high-income countries, but it constitutes up to 10% of malignancies in men in some African, Asian and South American regions . Evidence demonstrated that the tumor microenvironment (TME) plays a crucial role in the tumor progression and therapy response. Two landmarks of TME, extracellular matrix (ECM) remodeling and inflammation have been reported in these tumors. However, the cell types and cellular crosstalk involved in PeCa are widely unexplored. We used microarrays to identify enriched immune and stromal cells from the secretory profile of penile cancer transcriptomes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE196978 | GEO | 2022/08/16

REPOSITORIES: GEO

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