Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE197055 | GEO | 2022/02/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7

Project description: Not available

| S-SCDT-EMBOR-2021-54229-T | biostudies-other

KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7 [KFL10 overexpression]

Project description:Nonalcoholic steatohepatitis (NASH), characterized by hepatic steatosis, inflammation, and liver injury, has become a leading cause of end-stage liver diseases and liver transplantation. Krüppel-like factors 10 (KLF10) is a Cys2/His2 zinc finger transcription factor that regulates cell growth, apoptosis, and differentiation. However, whether it plays a role in the development and progression of chronic liver diseases like NASH remains poorly understood. In the present study, we found that KLF10 expression was selectively upregulated in the mouse models and human patients with NASH, compared with simple steatosis (NAFL). Gain- and loss-of function studies demonstrated that hepatocyte-specific overexpression of KLF10 aggravated, whereas its depletion alleviated diet-induced NASH pathogenesis in mice. Mechanistically, transcriptomic analysis and subsequent functional experiments showed that KLF10 promotes hepatic lipid accumulation and inflammation through the palmitoylation and plasma membrane localization of fatty acid translocase CD36 via transcriptionally activation of zDHHC7. Indeed, both expression of zDHHC7 and palmitoylation of CD36 are required for the pathogenic roles of KLF10 in NASH progression. Thus, our results identify an important role for KLF10 in NAFL-to-NASH development through zDHHC7-mediated CD36 palmitoylation.

2022-02-25 | GSE197054 | GEO

KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7 [NAFL vs NASH]

2022-02-25 | GSE197053 | GEO

KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7

Project description:KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7

| PRJNA808612 | ENA

KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7 [KFL10 overexpression]

Project description:KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7 [KFL10 overexpression]

| PRJNA808617 | ENA

KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7 [NAFL vs NASH]

Project description:KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7 [NAFL vs NASH]

| PRJNA808618 | ENA

Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2.

Project description: Not available

| S-EPMC8516465 | biostudies-literature

Sparcl1 promotes nonalcoholic steatohepatitis progression through upregulation of CCL2

Project description:1. White adipose tissues (WAT) are capable of secreting not only fatty acids but also a class of secretory proteins that modulate the homeostasis of distant organs, including the liver. To identify potential WAT-enriched secretory factors involved in NASH progression, C57BL/6 male mice were fed with a normal chow diet or HFHC diet for two different periods: 12 weeks and 28 weeks. Then, we compared the expression profile of epididymal WAT (eWAT) from mouse models of NAFL and NASH above mentioned by RNA-Sequencing analysis. 2. To investigate the contribution of Sparcl1 in the pathogenesis of NASH, male C57BL/6J mice were fed a HFHC diet for 12 weeks, and then intraperitoneal injected with saline or recombinant Sparcl1 protein (0.2mg/kg) every other day for 3 weeks. To elucidate the molecular basis of Sparcl1-mediated NASH progression, we conducted RNA-Sequencing analysis for differentially expressed genes using the livers of chronic recombinant Sparcl1 protein or saline- treated mice.

2021-06-10 | GSE176681 | GEO

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.

Project description: Not available

| S-EPMC3025083 | biostudies-literature

Sparcl1 promotes nonalcoholic steatohepatitis progression through upregulation of CCL2

Project description:Sparcl1 promotes nonalcoholic steatohepatitis progression through upregulation of CCL2

| PRJNA736749 | ENA