Transcriptomics

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Transcriptome profiling of left ventricles from Wildtype and KDM5B knockout mice


ABSTRACT: Myocardial fibrosis is the most common pathological feather of adverse ventricular remodeling, and persistent fibrotic extension decreases myocardial compliance, promotes the development of heart failure. Epigenetics has been considered to play a potent regulatory role in the development of excessive myocardial fibrosis. Although, the explicit mechanism of epigenetic regulation in myocardial fibrosis still needs to be fully elucidated.Transcriptome microarray analysis was used to screen differentially expressed genes in myocardial tissues from KDM5B KO and littermate control WT mice at day 7 after MI operation.

ORGANISM(S): Mus musculus

PROVIDER: GSE197223 | GEO | 2022/12/31

REPOSITORIES: GEO

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