Chronic exposure to waterpipe smoke elicits immunomodulatory and carcinogenic effects in the lung

ABSTRACT: Previous reports showed that cigarette smoke exposed normal-appearing airways in phenotypically lung cancer-free smokers carry alterations that are characteristic of tumors – suggestive of an airway field of injury. Very little is known of the effects of the chronic consumption of other forms of tobacco, such as waterpipe smoke (WPS), on lung pathobiology. Here we studied normal-appearing airway brushings from waterpipe smokers and those who were not exposed to WPS. We find that WPS elicits a molecular field of injury with gene programs that are pertinent to lung carcinogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE197653 | GEO | 2022/07/13

REPOSITORIES: GEO