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Analyses of prometastasic gene profile and immune infiltration in K7M2 osteosarcoma mouse model after treatment with SFV vectors expressing galectin-3 inhibitor.

ABSTRACT: RNA profiling of orthotopic K7M2 osteosarcoma mouse model treated with SFV-Gal3-N-C12, SFV-Luc or PBS (mock group). To better understand the mechanism underlying the therapeutic effect of SFV-Gal3-N-C12 we analyzed, in primary tumors of treated mices, the changes in expression of osteosarcoma-specific prometastasic genes as well as immunomodulatory molecules genes, and differences in immune cell infiltration.

ORGANISM(S): Mus musculus

PROVIDER: GSE197902 | GEO | 2022/08/24

REPOSITORIES: GEO

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