Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq of XBP1S and ATF6N cardiomyocytes

ABSTRACT: To characterize transcriptome changes uopn XBP1S and ATF6N overexpression in maturing cardiomyocytes

ORGANISM(S): Mus musculus

PROVIDER: GSE197965 | GEO | 2022/05/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-Seq of RYR2KO cardiomyocytes

Project description:To characterize transcriptome changes uopn RYR2 depletion in maturing cardiomyocytes

2022-05-21 | GSE179948 | GEO

RNA-Seq of ATF4 and DDIT3 OE cardiomyocytes

Project description:To characterize transcriptome changes uopn ATF4 or DDIT3 in maturing cardiomyocytes

2022-05-21 | GSE179944 | GEO

RNA-Seq of Ctrl, Myocd KO, Mrtfa/b DKO and TKO cardiomyocytes

Project description:To characterize transcriptome changes uopn Myocd KO, Mrtfa/b DKO and Mrtfa/b/Myocd TKO in maturing cardiomyocytes

2022-08-01 | GSE210085 | GEO

RNA-Seq of XBP1S and ATF6N cardiomyocytes

Project description:RNA-Seq of XBP1S and ATF6N cardiomyocytes

| PRJNA813138 | ENA

Genome-wide analysis of Xbp1s effect on gene expression in liver by Doxycycline induced TRE-Xbp1s overexpression in mouse

Project description:Analysis of Xbp1s overexpression in liver after 24 hr indution or 48 hr induction in LIXs mouse. As a control, WT mice after 2 hr refeed and 24 hr fast without refeed are used for analysis of postprandial gene expression. This microarray study was used to screen for target genes activated by Xbp1s in liver. Results provide important information for the role of Xbp1s during postprandial. Total RNA obtained from liver tissues from mice on Dox200 chow diet for 24 hr or 48 hr. Mice were fasted for 6 hr before sacrifice for liver.

2013-01-08 | E-GEOD-39301 | biostudies-arrayexpress

Adipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization

Project description:The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereby regulating systemic glucose homeostasis. Ectopic expression of XBP1s in adipocytes improves glucose tolerance and insulin sensitivity in both lean and obese (ob/ob) mice. The beneficial effect of adipocyte XBP1s on glucose homeostasis is associated with elevated serum levels of HMW adiponectin and indeed, is adiponectin dependent. Mechanistically, XBP1s promotes adiponectin multimerization rather than activating its transcription likely through a direct regulation of the expression of several ER-chaperones involved in adiponectin maturation, including Grp78, Pdia6, ERp44 and DsbA-L. Thus, we conclude that XBP1s is an important regulator of adiponectin multimerization, which may lead to a new therapeutic approach for the treatment of type 2 diabetes and hypoadiponectinemia. Epididymal adipose tissue from wild type and XBP1-overexpressing mice was subjected to gene expression profiling.

2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress

Genome-wide analysis of Xbp1s effect on gene expression in liver by Doxycycline induced TRE-Xbp1s overexpression in mouse

2013-01-08 | GSE39301 | GEO

XBP1s cutnrun

Project description:XBP1s cutnrun

| PRJNA949270 | ENA

XBP1s cutnrun

Project description:XBP1s cutnrun

| PRJNA887070 | ENA

Adipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization

2013-11-21 | GSE36031 | GEO