Transcriptomics

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Single cell analysis of iPSC-derived midbrain organoids (GBA1 mutant and controls)


ABSTRACT: Mutations in the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher´s disease, are the most frequent genetic risk factor for Parkinson’s disease (PD). Here, we employed single-cell genomic approaches in induced pluripotent stem cell (iPSC)-derived midbrain organoids to dissect the mechanisms underlying GCase-related neurodegeneration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198033 | GEO | 2023/03/06

REPOSITORIES: GEO

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