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Time-dependent transcriptomic changes in HNSCC cell lines after irradiation with photons or Carbon ions

ABSTRACT: Purpose: We aim to identify irradiation-induced transciptional changes in HPV-positive and HPV-negative HNSCC cell lines in vitro. Methods: Cells were seeded to tissue culture flasks and irradiated after adherence, with 0 Gy or 4 Gy carbon ions or 4 Gy photons or 8 Gy photons. Analysis was performed 4h and 48h and 72h after irradiation Results: Analysis of the data reveals a clear difference between irradiated and unirradiated samples, as well as between HPV-positive and HPV-negative HNSCC cells Conclusion: Transcriptomic changes are dependent on HPV Status and irradiation, but independent from the type of irradiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198100 | GEO | 2022/05/11

REPOSITORIES: GEO

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