Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcripts identified by microarray analysis that were deregulated in GFP positive cells of E11.5 Tbx18(GFP/GFP) and Tbx18(cre/+);HPRT(Tbx18VP16) kidney rudiments.

ABSTRACT: Evaluation of the transcriptional changes in E11.5 ureter mesenchyme cells upon loss of Tbx18 or overexpression of an activator version of Tbx18, respectively.

ORGANISM(S): Mus musculus

PROVIDER: GSE198129 | GEO | 2023/03/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcripts identified by microarray analysis that were deregulated in GFP positive cells of E11.5 Tbx18(GFP/GFP) and Tbx18(cre/+) HPRT(Tbx18VP16) kidney rudiments.

Project description:Transcripts identified by microarray analysis that were deregulated in GFP positive cells of E11.5 Tbx18(GFP/GFP) and Tbx18(cre/+) HPRT(Tbx18VP16) kidney rudiments.

| PRJNA813956 | ENA

Transcripts identified by microarray analysis that were deregulated in E15.5+6d Tbx18(cre/+);FGFR1(fl/fl);FGFR2(fl/fl) (Fgfr1/2cDKO) ureter cultures

Project description:Evaluation of the transcriptional changes in E15.5+6d ureter cultures upon loss of Fgfr1 and Fgfr2 in the ureteric mesenchyme.

2022-09-06 | GSE197368 | GEO

TBX18 regulates the differentiation of periductal smooth muscle stroma and the maintenance of epithelial integrity in the prostate

Project description:The T-box transcription factor TBX18 is essential to mesenchymal cell differentiation in several tissues and Tbx18 loss-of-function results in dramatic organ malformations and perinatal lethality. Here we demonstrate for the first time that Tbx18 is required for the normal development of periductal smooth muscle stromal cells in prostate, particularly in the anterior lobe, with a clear impact on prostate health in adult mice. Prostate abnormalities are only subtly apparent in Tbx18 mutants at birth; to examine postnatal prostate development we utilized a relatively long-lived hypomorphic mutant and a novel conditional Tbx18 allele. Similar to the ureter, cells that fail to express Tbx18 do not condense normally into smooth muscle cells of the periductal prostatic stroma. However, in contrast to ureter, the periductal stromal cells in mutant prostate assume a hypertrophic, myofibroblastic state and the adjacent epithelium becomes grossly disorganized. To identify molecular events preceding the onset of this pathology, we compared gene expression in the urogenital sinus (UGS), from which the prostate develops, in Tbx18-null and wild type littermates at two embryonic stages. Genes that regulate cell proliferation, smooth muscle differentiation, prostate epithelium development, and inflammatory response were significantly dysregulated in the mutant urogenital sinus around the time that Tbx18 is first expressed in the wild type UGS, suggesting a direct role in regulating those genes. Together, these results argue that Tbx18 is essential to the differentiation and maintenance of the prostate periurethral mesenchyme and that it indirectly regulates epithelial differentiation through control of stromal-epithelial signaling.

2016-04-26 | GSE80083 | GEO

Transcripts identified by microarray analysis that were deregulated in E14.5 Tbx18(cre/+);Gata6(fl/fl) (Gata6cKO) ureters

Project description:Evaluation of the transcriptional changes in E14.5 ureters upon loss of Gata6 in the ureteric mesenchyme.

2022-01-04 | GSE174614 | GEO

Transcripts identified by microarray analysis that were deregulated in P4 Tbx18(cre/+);Rbpj(fx/fx) (Rbpj-cKO) ureters

Project description:Evaluation of transcriptional changes in the P4 ureters upon loss of Rbpj in the urereteric mesenchyme.

2022-01-04 | GSE184597 | GEO

Transcripts identified by microarray analysis that were deregulated in E18.5 Tbx18(cre/+);Rbpj(fl/fl) (Rbpj-cKO) ureters

Project description:Evaluation of the transcriptional changes in E18.5 ureters upon loss of Rbpj in the ureteric mesenchyme.

2022-01-04 | GSE169662 | GEO

Transcripts identified by microarray analysis that were deregulated in E14.5 Tbx18(cre/+);Rbpj(fl/fl) (Rbpj-cKO) ureters

Project description:Evaluation of the transcriptional changes in E14.5 ureters upon loss of Rbpj in the ureteric mesenchyme.

2022-01-04 | GSE169661 | GEO

Transcripts identified by microarray analysis that were deregulated in E14.5 Tbx18(cre/+);FGFR1(fl/fl);FGFR2(fl/fl) (Fgfr1/2cDKO) ureters

Project description:Evaluation of the transcriptional changes in E14.5 ureters upon loss of Fgfr1 and Fgfr2 in the ureteric mesenchyme.

2022-09-06 | GSE197369 | GEO

An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages

Project description:The evolutionarily conserved transcription factor, Tbx18, is expressed in a dynamic pattern throughout embryonic and early postnatal life and plays crucial roles in the development of multiple organ systems. Previous studies have indicated that this dynamic function is controlled by an expansive regulatory architecture, extending far upstream and downstream of the gene. With the goal of identifying elements that interact with the Tbx18 promoter in developing prostate, we coupled chromatin conformation capture (4C) and ATAC-seq from embryonic day 18.5 (E18.5) mouse urogenital sinus (UGS), where Tbx18 is highly expressed. The data revealed dozens of active chromatin elements distributed throughout a 1.5 million base pair topologically associating domain (TAD). To identify cell types contributing to this chromatin signal, we used lineage tracing methods with a Tbx18 Cre “knock-in” allele; these data show clearly that Tbx18-expressing precursors differentiate into wide array of cell types in multiple tissue compartments, most of which have not been previously reported. We also used a 209 kb Cre-expressing Tbx18 transgene, to partition enhancers for specific precursor types into two rough spatial domains. Within this central 209 kb compartment, we identified ECR1, previously described to regulate Tbx18 expression in ureter, as an active regulator of UGS expression. Together these data define the diverse fates of Tbx18+ precursors in prostate-associated tissues for the first time, and identify a highly active TAD controlling the gene’s essential function in this tissue.

2018-12-29 | GSE123102 | GEO

Transcripts identified by microarray analysis that were deregulated in E15.5+6d Tbx18(cre/+) FGFR1(fl/fl) FGFR2(fl/fl) (Fgfr1/2cDKO) ureter cultures

Project description:Transcripts identified by microarray analysis that were deregulated in E15.5+6d Tbx18(cre/+) FGFR1(fl/fl) FGFR2(fl/fl) (Fgfr1/2cDKO) ureter cultures

| PRJNA810041 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data