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RNA-seq (3-prime): Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

ABSTRACT: The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE198137 | GEO | 2022/03/10

REPOSITORIES: GEO

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MethylC-Seq: Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Project description:The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.

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Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-10 | GSE198139 | GEO

m6A modification segregates the stemness program from proliferation in ISCs [ChIP-seq]

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| S-EPMC5790837 | biostudies-literature

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