Polygenic and directional regulatory evolution across pathways in Saccharomyces
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ABSTRACT: We assess the prevalence of polygenic evolution in pathways between the yeasts S. cerevisiae and S. bayanus. We first established short-read sequencing methods to detect cis-regulatory variation in a diploid hybrid between the species. We then formulated an analytic strategy to test for the scenario in which selective pressure in one species, to increase or decrease the activity of a pathway, has driven the accumulation of cis-regulatory variants that act in the same direction on gene expression. Application of this test revealed a variety of yeast pathways with evidence for directional regulatory evolution.
ORGANISM(S): Saccharomyces bayanus x Saccharomyces cerevisiae
PROVIDER: GSE19837 | GEO | 2010/02/22
SECONDARY ACCESSION(S): PRJNA122057
REPOSITORIES: GEO
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