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Single-cell profiling of human adipose tissue-derived mesenchymal progenitor cells induced toward adipogenic fate.

ABSTRACT: To understand the specific transcriptomic changes in cells undergoing adipogenic differentiation, we performed single cell RNA-seq on two separate cultures: one corresponding to multipotent progenitors grown to confluency but not subjected to differentiation stimuli, and the second corresponding to progenitors exposed to adipogenic media for 3 days. Homogenous multipotent progenitors underwent two distinct fate trajectories rapidly upon induction of adipose differentiation, one toward the adipocyte fate, and the other towards a distinct, undifferentiated state.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198482 | GEO | 2023/04/01

REPOSITORIES: GEO

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