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Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses

ABSTRACT: By combining single cell transcriptomics and proteomics approaches, with lineage tracing and adoptive transfer experiments, we next demonstrate that tDC originate from a bone marrow precursor shared with plasmacytoid DCs (pDCs). Using new lineage tracing mouse models, we evaluated tDC plasticity and reveal their acquisition of Esamhi conventional DC type 2 (cDC2) features. Finally, we present tDC capacity to quickly response to stimulation and potently activate antigen-specific naïve T cells, demonstrating that these cells harbor functions of differentiated DCs. Our findings clarify tDC nature and reveal these cells as a unique lineage of DCs related developmentally to pDCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE198720 | GEO | 2023/05/23

REPOSITORIES: GEO

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