Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing of normal and unilateral ureteral obstruction (UUO) operated mouse kidneys

ABSTRACT: RNA-sequencing of mouse left kidneys for which the left ureter was obstructed (UUO) or not obstructed (sham) animals, isolated 14 days after the surgery

ORGANISM(S): Mus musculus

PROVIDER: GSE198962 | GEO | 2025/03/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA sequencing of sham-operated and unilateral ureteral obstruction (UUO)-operated mouse kidneys in Pax8Cre+ and Kdm6afl/Y Pax8Cre+ knockout mice

Project description:RNA-sequencing of mouse left kidneys for which the left ureter was obstructed (UUO) or not obstructed (sham) animals, isolated 7 days after the surgery in normal mice and mice in which the Kdm6a gene was deleted from tubule epithelial cells

2023-09-01 | GSE205759 | GEO

RNA sequencing analysis of mouse kidney fibroblasts isolated from control kidneys or UUO surgery operated kidneys

Project description:RNA sequencing of fibroblasts isolated from mouse kidneys which were either subjected to left ureter obstruction (UUO) or non obstructed (Control) conditions

2025-03-17 | GSE198829 | GEO

RNA sequencing of normal and unilateral ureteral obstruction (UUO) operated mouse kidneys

Project description:RNA sequencing of normal and unilateral ureteral obstruction (UUO) operated mouse kidneys

| PRJNA817581 | ENA

Transcriptome analysis of kidneys of acute-chronic (AC), unilateral ureteral obstruction (UUO) mice and their respective controls

Project description:Significant renal fibrosis and a significant increase in serum creatinine were observed in AC model mice and UUO model mice, and the same pattern of fibrosis was observed in the cortex and medulla. Compared with sham operation, RNA-Seq detected circRNAs that were differentially expressed in the two models.

2022-03-01 | GSE192791 | GEO

Label-free quantitative proteomics for mouse kidney tissue of unilateral ureteral obstruction (UUO) vs Sham.

Project description:Label-free quantitative proteomics for mouse kidney tissue of UUO vs Sham was used for discovery of differential expressed proteins in the process of renal fibrosis. Compared to sham mice, we found that 216 upregulated proteins and 215 downregulated proteins in UUO mice according to fold change ≥ 5, adjusted-p ≤ 0.01. Then, we will study the potential mechanism according to differential expressed proteins.

2022-09-30 | PXD029310 | Pride

Axl targeting in experimental unilateral ureteral obstruction

Project description:We investigated if Axl receptor tyrosine kinase was up-regulated in unilateral ureteral obstruction (UUO) and if blocking of Axl by a small molecule called BGB324 (also called Bemcentinib) reduces fibrosis development in the ligated kidney as compared to treatment with its vehicle alone.

2019-03-01 | GSE123674 | GEO

Expression data from renal fibrotic tissues in two rat models induced by unilateral ureteral obstruction (UUO) and adenine

Project description:Renal fibrosis (RF) is the common pathological outcome and central treatment target of multiple chronic kidney diseases. Currently, the molecular mechanisms of RF remain poorly understood. Therefore, this study aimed to established the adenine- and UUO-induced rat models, identified differentially expressed genes in their renal tissues using RNA-Seq analysis, and screened RF-related hub targets and key pathways.

2022-10-31 | GSE216376 | GEO

Microarray analysis revealed novel genes and pathways associated with neonatal unilateral ureteral obstruction

Project description:Congenital obstructive nephropathy (CON) is the leading cause of pediatric chronic kidney diseases with high morbidity and mortality.To identify differentially expressed genes, microarray analysis was performed using the unilateral ureteral obstruction (UUO)-induced neonatal rat model of CON.

2017-01-26 | E-MTAB-4984 | biostudies-arrayexpress

Proteomics of obstructed kidneys from patients with obstructive nephropathy and unilateral ureteral obstruction mice

Project description:Here, we performed proteomics of kidneys obtained from patients with obstructive nephropathy and healthy controls (n=11/8), or from unilateral ureteral obstruction (UUO) mice and sham mice (n=6/6). Proteomic measurement of all human kidney samples resulted in a total of 6089 proteins with an average of 5780 proteins per sample. Compared to control kidneys, 614 proteins were up-regulated and 855 proteins were down-regulated (p value < 0.05, q value < 0.05, and fold change > 2 or < 0.5) in human obstructed kidneys. The up-regulated proteins were significantly enriched in collagen formation and immune response. Moreover, the human and mouse kidney proteomics reveled an aberrant NAD+ metabolism and NAD+-related metabolic pathways, including mitochondrial dysfunction, oxidative phosphorylation, and tryptophan metabolism. The expression patterns of several key enzymes catalyzing NAD+ biosynthesis and consumption were dramatically altered in obstructive nephropathy. Moreover, the major NAD+ consumer CD38 was strongly induced in obstructed kidneys which contributed to the decline of renal NAD+ levels. Functional studies demonstrated that CD38 deletion or inhibition significantly recovered renal NAD+ levels and reduced obstruction-induced renal fibrosis.

2023-01-08 | PXD039314 |

Exploring new pathways involved during experimental renal fibrogenesis in the Unilateral Ureteral Obstruction

Project description:Chronic kidney disease (CKD) is a burden for Public Health and concerns millions of individuals worldwide. Independently of the cause, CKD is secondary to the replacement of functional renal tissue by extra-cellular matrix proteins (i.e fibrosis) that progressively impairs kidney function. The pathophysiological pathways that control the development of renal fibrosis are common to most of the nephropathies involving native kidneys or kidney grafts. Unfortunately, very few treatments are available to stop renal fibrosis and most of the therapeutic strategies are often barely able to slow down the progression of fibrogenesis in native kidneys. Therefore, it is mandatory to discover new therapeutic pathways to stop renal fibrosis. Our objective is to study new pathways involved in renal fibrosis. We thus decided to use the model of Unilateral Ureteral renal Obstruction in mice, a fast and reproducible experimental model of renal fibrosis. We studied renal fibrosis using experimental model of ureteral unilateral obstruction in mice, which was performed by complete ligation of the left ureter. The control lateral right kidney served as internal control.

2013-02-10 | E-GEOD-38117 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data