Transcriptomics

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Venetoclax cooperates with ionizing radiation to attenuate Diffuse Midline Glioma tumor growth


ABSTRACT: This article highlights the radiation induced cytotoxic effect of the BCL2 inhibitor, venetoclax, in diffuse midline gliomas (DMG). 1. RNA-seq: We performed bulk RNA sequencing of DMG cells exposed to 6Gy radiation and found the genes upregulated after radiation compared to unirradiated controls. 2. DNA Repair shRNA screen: We also performed a DNA Repair shRNA screen and identified the genes which are responsible for radioresistance in DMG.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198979 | GEO | 2022/03/23

REPOSITORIES: GEO

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